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Carbon dioxide: a renewable feedstock for the synthesis of fine and bulk chemicals

Yogesh P. PATIL, Pawan J. TAMBADE, Sachin R. JAGTAP, Bhalchandra M. BHANAGE,

《化学科学与工程前沿（英文）》 2010年第4卷第2期页码 213-235 doi: 10.1007/s11705-009-0227-0

摘要： The syntheses of carbon dioxide (CO) based industrially important chemicals have gained considerable interest in view of the sustainable chemistry and “green chemistry” concepts. In this review, recent developments in the chemical fixation of CO to valuable chemicals are discussed. The synthesis of five-member cyclic carbonates , cycloaddition of CO to epoxides is one of the promising reactions replacing the existing poisonous phosgene-based synthetic route. This review focuses on the synthesis of cyclic carbonates, vinyl carbamates, and quinazoline-2,4(1,3)-diones reaction of CO and epoxide, amines/phenyl acetylene, 2-aminobenzinitrile and other chemicals. Direct synthesis of dimethyl carbonate, 1,3-disubstituted urea and 2-oxazolidinones/2-imidazolidinones have limitations at present because of the reaction equilibrium and chemical inertness of CO. The preferred alternatives for their synthesis like transesterification of ethylene carbonate with methanol, transamination of ethylene carbonate with primary amine and transamination reaction of ethylene carbonate with diamines/-aminoalcohols are discussed. These methodologies offer marked improvements for greener chemical fixation of CO in to industrially important chemicals.

关键词： inertness CO phosgene-based synthetic quinazoline-2 4 equilibrium

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Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 37-45 doi: 10.1007/s11705-017-1618-2

摘要： The ability to go from a digitized DNA sequence to a predictable biological function is central to synthetic biology. Genome engineering tools facilitate rewriting and implementation of engineered DNA sequences. Recent development of new programmable tools to reengineer genomes has spurred myriad advances in synthetic biology. Tools such as clustered regularly interspace short palindromic repeats enable RNA-guided rational redesign of organisms and implementation of synthetic gene systems. New directed evolution methods generate organisms with radically restructured genomes. These restructured organisms have useful new phenotypes for biotechnology, such as bacteriophage resistance and increased genetic stability. Advanced DNA synthesis and assembly methods have also enabled the construction of fully synthetic organisms, such as J. Craig Venter Institute (JCVI)-syn 3.0. Here we summarize the recent advances in programmable genome engineering tools.

关键词： CRISPR genome engineering synthetic biology rational design

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A new polystyrene-latex-based and EPS-containing synthetic sludge

Ling-Ling Wang, Shan Chen, Hai-Ting Zheng, Guo-Qing Sheng, Zhi-Jun Wang, Wen-Wei Li, Han-Qing Yu

《环境科学与工程前沿（英文）》 2012年第6卷第1期页码 131-139 doi: 10.1007/s11783-011-0390-7

摘要： Since the living microorganisms in activated sludge continuously change, it is difficult to conduct controlled experiments and achieve reproducible results for evaluating sludge characteristics. Synthetic sludge, as a chemical surrogate to activated sludge, could be used to investigate the sludge physicochemical properties, and it is desirable to prepare synthetic sludge with similar structure and properties to real activated sludge to explore the flocculation and settlement processes in activated sludge systems. In this work, a high-strength synthetic sludge was prepared with functional polystyrene latex particles as the framework and extracellular polymeric substances (EPS) to modify its surface. The flocculation and settling characteristics of the microspheres and the prepared synthetic sludge were tested. Compared with other three functional polystyrene latex microspheres, the synthetic sludge prepared with EPS-modified polystyrene latex microspheres showed good settling characteristics and a significantly higher strength. They could be used for studying the physicochemical properties of activated sludge.

关键词： activated sludge extracellular polymeric substances (EPS) flocculation polystyrene latex particles synthetic sludge

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基于Vague集的系统安全综合评价

刘爱华,施式亮,吴　超

《中国工程科学》 2007年第9卷第3期页码 58-61

摘要：

系统安全中存在含糊性和不可分辨性，Fuzzy综合评价只能从正面解决含糊性问题，而Vague集具有对不确定数据更强、更灵活的直觉表达能力，由此提出把Vague集运用到综合评价当中，并使用改进层次分析法确定各评价指标的权重，建立了基于Vague集的系统安全综合评价模型。通过对陕西某高层建筑火灾危险评价实例证明，该模型能使系统安全评价结果更准确、合理。

关键词：系统安全 Vague集综合评价权重

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Mobile CRISPR-Cas9 based anti-phage system in E. coli

《化学科学与工程前沿（英文）》 2022年第16卷第8期页码 1281-1289 doi: 10.1007/s11705-022-2141-7

摘要： Escherichia coli is one of the most important microbial cell factories, but infection by bacteriophages in the environment may have a huge impact on its application in industrial production. Here, we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in E. coli. Two conjugative plasmids pGM1 (phosphoglucomutase 1) and pGM2 carrying one and two guide RNAs, respectively, were designed to defend against a filamentous phage. The results showed that the pGM1 and pGM2 could decrease the phage infection rate to 1.6% and 0.2% respectively in infected cells. For preventing phage infection in E. coli, the pGM2 decreased the phage infection rate to 0.1%, while pGM1 failed to block phage infection. Sequence verification revealed that point mutations in protospacer or protospacer adjacent motif sequences of the phage genome caused loss of the defense function. These results support the potential application of MCBAS in E. coli cell factories to defend against phage infections.

关键词： phage infections anti-phage CRISPR-Cas9 conjugative transfer synthetic biology

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Renewable synthetic fuel: turning carbon dioxide back into fuel

《能源前沿（英文）》 2022年第16卷第2期页码 145-149 doi: 10.1007/s11708-022-0828-6

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

《医学前沿（英文）》 2021年第15卷第4期页码 541-550 doi: 10.1007/s11684-020-0780-y

摘要： Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny but not for normal cells. We further discuss strategies to identify these functional nodes in the context of synthetic lethality. We review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.

关键词： synthetic lethality undruggable transcription factor c-Myc

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Water-soluble BODIPY and aza-BODIPY dyes: synthetic progress and applications

Gang FAN,Le YANG,Zhijian CHEN

《化学科学与工程前沿（英文）》 2014年第8卷第4期页码 405-417 doi: 10.1007/s11705-014-1445-7

摘要： In recent years, boron-dipyrromethene (BODIPY) and boron-azadipyrromethene (aza-BODIPY) dyes have attracted considerable multidisciplinary attention due to their diverse applications. By introducing various hydrophilic groups, such as quaternary ammonium, sulfonate or oligo-ethyleneglycol moieties into the BODIPY core, the solubilities of these dyes in aqueous solution can be greatly improved while maintaining their high fluorescence quantum yields. Accordingly, applying these fluorescent dyes in aqueous systems to areas such as chemosensors, biomacromolecule labeling, bio-imaging and photodynamic therapy has been achieved. In this article, the recent progress on the synthesis, optical properties and application of water-soluble BODIPY dyes and aza-BODIPY dyes is reviewed.

关键词： boron-dipyrromethene boron-azadipyrromethene synthetic progress applications

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Removal efficiencies of natural and synthetic progesterones in hospital wastewater treated by different

《环境科学与工程前沿（英文）》 2022年第16卷第10期 doi: 10.1007/s11783-022-1558-z

摘要：

● The concentrations of 61 progesterones in HWW, PFTE, SBTE were evaluated.

关键词： Progesterones Hospital wastewater Primary filtration treatment effluent Secondary biological treatment effluent Disinfection process

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SCRaMbLE drive application of synthetic yeast genome

Jin Jin, Yuan Ma, Duo Liu

《化学科学与工程前沿（英文）》 2018年第12卷第4期页码 832-834 doi: 10.1007/s11705-018-1749-0

摘要：

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Hollow-fiber gas penetration electrodes efficiently produce renewable synthetic fuels

《能源前沿（英文）》 2022年第16卷第5期页码 700-705 doi: 10.1007/s11708-022-0842-8

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合成橡胶化学及技术进展

武冠英

《中国工程科学》 1999年第1卷第3期页码 79-85

摘要：

文章从合成橡胶的化学基础出发，叙述了合成橡胶工业二十世纪以来的过去、现状，并展望未来。着重讨论了合成化学基础及相应聚合工艺过程的进步这两方面的问题。指出合成橡胶化学基础中活性聚合、可控聚合，包括茂金属催化剂仍为近期的重点；气相聚合工艺将会得到较大的发展；高效聚合釜的研究仍是核心问题；环保问题应更受到重视。

关键词：合成橡胶合成化学活性/控制聚合气相聚合

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Cell-free systems in the new age of synthetic biology

Fernando Villarreal,Cheemeng Tan

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 58-65 doi: 10.1007/s11705-017-1610-x

摘要： The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of their composition. Here, we discuss the historical advancement of cell-free systems, as well as their new applications in the rapid design of synthetic genetic circuits and components, directed evolution of biomolecules, diagnosis of infectious diseases, and synthesis of vaccines. Finally, we present our vision on the future direction of cell-free synthetic biology.

关键词： cell-free system application

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polygeneration system of a combination of the gasified coal gas and the pyrolyzed coal gas to form the synthetic

Kechang XIE, Fan LI

《化学科学与工程前沿（英文）》 2010年第4卷第4期页码 383-384 doi: 10.1007/s11705-010-0526-5